Clinical mutational profiling and categorization of BRAF mutations in melanomas using next generation sequencing

BACKGROUND: Analysis of melanomas for actionable mutations has become the standard of care. Recently, a classification scheme has been proposed that categorizes BRAF mutations based on their mechanisms for activation of the MAPK pathway. METHODS: In this analysis BRAF, KIT, NRAS, and PIK3CA mutation...

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Publicado en:BMC Cancer
Autores principales: Lokhandwala, Parvez M., Tseng, Li-Hui, Rodriguez, Erika, Zheng, Gang, Pallavajjalla, Aparna, Gocke, Christopher D., Eshleman, James R., Lin, Ming-Tseh
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612071/
https://ncbi.nlm.nih.gov/pubmed/31277584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-5864-1
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