Heterogeneity of resistance mutations detectable by next-generation sequencing in TKI-treated lung adenocarcinoma

EGFR-mutated lung adenocarcinomas routinely develop resistance to tyrosine kinase inhibitors (TKI). To better characterize the relative frequencies of the resistance mechanisms, we analyzed 48 EGFR-mutated TKI-resistant specimens from 41 patients. Next-generation sequencing of post-treatment specime...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Belchis, Deborah A., Tseng, Li-Hui, Gniadek, Thomas, Haley, Lisa, Lokhandwala, Parvez, Illei, Peter, Gocke, Christopher D., Forde, Patrick, Brahmer, Julie, Askin, Frederic B., Eshleman, James R., Lin, Ming-Tseh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216719/
https://ncbi.nlm.nih.gov/pubmed/27304188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9931
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