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Clinical detection and categorization of uncommon and concomitant mutations involving BRAF
BACKGROUND: Selective BRAF inhibitors, vemurafenib and dabrafenib, and the MEK inhibitor, trametinib, have been approved for treatment of metastatic melanomas with a BRAF p.V600E mutation. The clinical significance of non-codon 600 mutations remains unclear, in part, due to variation of kinase activ...
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| Publié dans: | BMC Cancer |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4619530/ https://ncbi.nlm.nih.gov/pubmed/26498038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1811-y |
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