Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A

Ric-8A is a 530-amino acid cytoplasmic molecular chaperone and guanine nucleotide exchange factor (GEF) for i, q, and 12/13 classes of heterortrimeric G protein alpha subunits (Gα). We report the 2.2-Å crystal structure of the Ric-8A Gα-binding domain with GEF activity, residues 1–452, and is phosph...

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Publicado no:Structure
Main Authors: Zeng, Baisen, Mou, Tung-Chung, Doukov, Tzanko I., Steiner, Andrea, Yu, Wenxi, Papasergi-Scott, Makaia, Tall, Gregory G., Hagn, Franz, Sprang, Stephen R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610710/
https://ncbi.nlm.nih.gov/pubmed/31155309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.04.013
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