Generation of High-Titer Self-Inactivated γ-Retroviral Vector Producer Cells

The γ-retroviral vector is a gene delivery vehicle that is commonly used in gene therapy. Despite its efficacy, its strong enhancers contributed to malignant transformations in some hematopoietic stem cell (HSC) gene therapy trials. A safer version without viral enhancers (SIN) is available, but its...

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Bibliografiska uppgifter
I publikationen:Mol Ther Methods Clin Dev
Huvudupphovsmän: Ghani, Karim, Boivin-Welch, Michael, Roy, Sylvie, Dakiw-Piaceski, Angela, Barbier, Martin, Pope, Elena, Germain, Lucie, Caruso, Manuel
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Gene & Cell Therapy 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610700/
https://ncbi.nlm.nih.gov/pubmed/31312667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.05.013
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