Huntington’s Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support

In Huntington’s disease (HD), while the ubiquitously expressed mutant Huntingtin (mtHTT) protein primarily compromises striatal and cortical neurons, glia also undergo disease-contributing alterations. Existing HD models using human induced pluripotent stem cells (iPSCs) have not extensively charact...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Garcia, Veronica J., Rushton, David J., Tom, Colton M., Allen, Nicholas D., Kemp, Paul J., Svendsen, Clive N., Mattis, Virginia B.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610155/
https://ncbi.nlm.nih.gov/pubmed/31316341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2019.00669
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