Huntington’s Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support

In Huntington’s disease (HD), while the ubiquitously expressed mutant Huntingtin (mtHTT) protein primarily compromises striatal and cortical neurons, glia also undergo disease-contributing alterations. Existing HD models using human induced pluripotent stem cells (iPSCs) have not extensively charact...

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Dades bibliogràfiques
Publicat a:Front Neurosci
Autors principals: Garcia, Veronica J., Rushton, David J., Tom, Colton M., Allen, Nicholas D., Kemp, Paul J., Svendsen, Clive N., Mattis, Virginia B.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610155/
https://ncbi.nlm.nih.gov/pubmed/31316341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2019.00669
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