Inhibition of cisplatin-resistant head and neck squamous cell carcinoma by combination of Afatinib with PD0325901, a MEK inhibitor

ErbB family members that contain EGFR, HER2, HER3 and HER4 play important roles in many cancer types, including head and neck; however, inhibition of these receptors by small molecule kinase inhibitors showed limited results due to compensatory up-regulation of some key survival signaling pathways....

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Dettagli Bibliografici
Pubblicato in:Am J Cancer Res
Autori principali: Lin, Xiaofeng, Liao, Jipei, Yang, Zejia, Fan, Xiaoxuan, Cullen, Kevin J, Chen, Long, Dan, Hancai
Natura: Artigo
Lingua:Inglês
Pubblicazione: e-Century Publishing Corporation 2019
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610054/
https://ncbi.nlm.nih.gov/pubmed/31285959
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