Inhibition of IKKβ/NF-κB signaling pathway to improve Dasatinib efficacy in suppression of cisplatin-resistant head and neck squamous cell carcinoma

Proto-oncogene tyrosine-protein kinase Src plays an important role in Head and Neck Squamous Cell Carcinoma (HNSCC). However, the FDA-approved SRC inhibitor Dasatinib shows very limited efficacy in HNSCC clinical trials, even though Dasatinib can completely inhibit SRC in the laboratory setting. The...

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Vydáno v:Cell Death Discov
Hlavní autoři: Yang, Zejia, Liao, Jipei, Cullen, Kevin J., Dan, Hancai
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229171/
https://ncbi.nlm.nih.gov/pubmed/32435511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-0270-7
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