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Losartan and vitamin D inhibit colonic tumor development in a conditional Apc-deleted mouse model of sporadic colon cancer
Colorectal cancer (CRC) is a leading cause of cancer-deaths. The renin-angiotensin system (RAS) is up-regulated in CRC and epidemiological studies suggest RAS inhibitors reduce cancer risk. Since vitamin D receptor negatively regulates renin, we examined anti-cancer efficacy of vitamin D (VD) and lo...
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| Publicado no: | Cancer Prev Res (Phila) |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6609481/ https://ncbi.nlm.nih.gov/pubmed/31088824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-18-0380 |
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