Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis

Clonal hematopoiesis (CH) is a common aging-associated condition with increased risk of hematologic malignancy. Knowledge of the mechanisms driving evolution from CH to overt malignancy has been hampered by a lack of in vivo models that orthogonally activate mutant alleles. Here, we develop independ...

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Bibliographic Details
Published in:Leukemia
Main Authors: Loberg, Matthew A., Bell, Rebecca K., Goodwin, Leslie O., Eudy, Elizabeth, Miles, Linde A., SanMiguel, Jennifer M., Young, Kira, Bergstrom, David E., Levine, Ross L., Schneider, Rebekka K., Trowbridge, Jennifer J.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609470/
https://ncbi.nlm.nih.gov/pubmed/30692594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0368-6
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