Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis

Clonal hematopoiesis (CH) is a common aging-associated condition with increased risk of hematologic malignancy. Knowledge of the mechanisms driving evolution from CH to overt malignancy has been hampered by a lack of in vivo models that orthogonally activate mutant alleles. Here, we develop independ...

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Pubblicato in:Leukemia
Autori principali: Loberg, Matthew A., Bell, Rebecca K., Goodwin, Leslie O., Eudy, Elizabeth, Miles, Linde A., SanMiguel, Jennifer M., Young, Kira, Bergstrom, David E., Levine, Ross L., Schneider, Rebekka K., Trowbridge, Jennifer J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609470/
https://ncbi.nlm.nih.gov/pubmed/30692594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0368-6
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