Complex karyotype in de novo acute myeloid leukemia: typical and atypical subtypes differ molecularly and clinically

Complex karyotype (CK) with ≥3 abnormalities is detected in 10-12% of patients with acute myeloid leukemia (AML) and associated with poor prognosis. The most common unbalanced abnormalities found in CK result in loss of material from the 5q, 7q and/or 17p chromosome arms. The presence of 5q, 7q and/...

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Veröffentlicht in:Leukemia
Hauptverfasser: Mrózek, Krzysztof, Eisfeld, Ann-Kathrin, Kohlschmidt, Jessica, Carroll, Andrew J., Walker, Christopher J., Nicolet, Deedra, Blachly, James S., Bill, Marius, Papaioannou, Dimitrios, Wang, Eunice S., Uy, Geoffrey L., Kolitz, Jonathan E., Powell, Bayard L., Blum, William, Stone, Richard M., Byrd, John C., Bloomfield, Clara D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609457/
https://ncbi.nlm.nih.gov/pubmed/30737482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0390-3
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