Probing α(4)βδ GABA(A) Receptor Heterogeneity: Differential Regional Effects of a Functionally Selective α(4)β(1)δ/α(4)β(3)δ Receptor Agonist on Tonic and Phasic Inhibition in Rat Brain

In the present study, the orthosteric GABA(A) receptor (GABA(A)R) ligand 4,5,6,7-tetrahydroisothiazolo[5,4-c]pyridin-3-ol (Thio-THIP) was found to possess a highly interesting functional profile at recombinant human GABA(A)Rs and native rat GABA(A)Rs. Whereas Thio-THIP displayed weak antagonist acti...

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Vydáno v:J Neurosci
Hlavní autoři: Hoestgaard-Jensen, Kirsten, Dalby, Nils Ole, Krall, Jacob, Hammer, Harriet, Krogsgaard-Larsen, Povl, Frølund, Bente, Jensen, Anders A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608486/
https://ncbi.nlm.nih.gov/pubmed/25471566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1495-14.2014
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