Immune-Induced Fever Is Mediated by IL-6 Receptors on Brain Endothelial Cells Coupled to STAT3-Dependent Induction of Brain Endothelial Prostaglandin Synthesis

The cytokine IL-6, which is released upon peripheral immune challenge, is critical for the febrile response, but the mechanism by which IL-6 is pyrogenic has remained obscure. Here we generated mice with deletion of the membrane bound IL-6 receptor α (IL-6Rα) on neural cells, on peripheral nerves, o...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Eskilsson, Anna, Mirrasekhian, Elahe, Dufour, Sylvie, Schwaninger, Markus, Engblom, David, Blomqvist, Anders
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2014
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Brief Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608482/
https://ncbi.nlm.nih.gov/pubmed/25429137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3520-14.2014
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