Deletion of Prostaglandin E(2) Synthesizing Enzymes in Brain Endothelial Cells Attenuates Inflammatory Fever

Fever is a hallmark of inflammatory and infectious diseases. The febrile response is triggered by prostaglandin E(2) synthesis mediated by induced expression of the enzymes cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase 1 (mPGES-1). The cellular source for pyrogenic PGE(2) remains...

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Publié dans:J Neurosci
Auteurs principaux: Wilhelms, Daniel Björk, Kirilov, Milen, Mirrasekhian, Elahe, Eskilsson, Anna, Kugelberg, Unn Örtegren, Klar, Christine, Ridder, Dirk A., Herschman, Harvey R., Schwaninger, Markus, Blomqvist, Anders, Engblom, David
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2014
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608410/
https://ncbi.nlm.nih.gov/pubmed/25164664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1838-14.2014
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