Immune-Induced Fever Is Dependent on Local But Not Generalized Prostaglandin E(2) Synthesis in the Brain

Fever occurs upon binding of prostaglandin E(2) (PGE(2)) to EP(3) receptors in the median preoptic nucleus of the hypothalamus, but the origin of the pyrogenic PGE(2) has not been clearly determined. Here, using mice of both sexes, we examined the role of local versus generalized PGE(2) production i...

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Publicado en:J Neurosci
Autores principales: Eskilsson, Anna, Matsuwaki, Takashi, Shionoya, Kiseko, Mirrasekhian, Elahe, Zajdel, Joanna, Schwaninger, Markus, Engblom, David, Blomqvist, Anders
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2017
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596481/
https://ncbi.nlm.nih.gov/pubmed/28438967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3846-16.2017
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