Immune-Induced Fever Is Dependent on Local But Not Generalized Prostaglandin E(2) Synthesis in the Brain

Fever occurs upon binding of prostaglandin E(2) (PGE(2)) to EP(3) receptors in the median preoptic nucleus of the hypothalamus, but the origin of the pyrogenic PGE(2) has not been clearly determined. Here, using mice of both sexes, we examined the role of local versus generalized PGE(2) production i...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Eskilsson, Anna, Matsuwaki, Takashi, Shionoya, Kiseko, Mirrasekhian, Elahe, Zajdel, Joanna, Schwaninger, Markus, Engblom, David, Blomqvist, Anders
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596481/
https://ncbi.nlm.nih.gov/pubmed/28438967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3846-16.2017
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