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Immune-Induced Fever Is Dependent on Local But Not Generalized Prostaglandin E(2) Synthesis in the Brain
Fever occurs upon binding of prostaglandin E(2) (PGE(2)) to EP(3) receptors in the median preoptic nucleus of the hypothalamus, but the origin of the pyrogenic PGE(2) has not been clearly determined. Here, using mice of both sexes, we examined the role of local versus generalized PGE(2) production i...
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| Publicado en: | J Neurosci |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Society for Neuroscience
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6596481/ https://ncbi.nlm.nih.gov/pubmed/28438967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3846-16.2017 |
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