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Delayed administration of anti‐PD‐1 antibody reverses immune dysfunction and improves survival during sepsis

There is increasing recognition that a major pathophysiologic event in sepsis is the progression to an immunosuppressive state in which the host is unable to eradicate invading pathogens. Although there are likely numerous causes for the immunosuppression, expression of negative costimulatory molecu...

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Détails bibliographiques
Publié dans:J Leukoc Biol
Auteurs principaux: Brahmamdam, Pavan, Inoue, Shigeaki, Unsinger, Jacqueline, Chang, Katherine C., McDunn, Jonathan E., Hotchkiss, Richard S.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6607999/
https://ncbi.nlm.nih.gov/pubmed/20483923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0110037
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