Targeted delivery of siRNA to cell death proteins in sepsis

Immune suppression is a major cause of morbidity and mortality in the septic patient. Apoptotic loss of immune effector cells such as CD4 T and B cells is a key component in the loss immune competence in sepsis. Inhibition of lymphocyte apoptosis has led to improved survival in animal models of seps...

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Main Authors: Brahmamdam, Pavan, Watanabe, Eizo, Unsinger, Jacqueline, Chang, Katherine C., Schierding, William, Hoekzema, Andrew S., Zhou, Tony T., McDonough, Jacquelyn S., Holemon, Heather, Heidel, Jeremy D., Coopersmith, Craig M., McDunn, Jonathan E., Hotchkiss, Richard S.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950011/
https://ncbi.nlm.nih.gov/pubmed/19033888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0b013e318194bcee
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