ULK1‐mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 Crohn's mutant

Autophagy is a highly regulated catabolic pathway that is potently induced by stressors including starvation and infection. An essential component of the autophagy pathway is an ATG16L1‐containing E3‐like enzyme, which is responsible for lipidating LC3B and driving autophagosome formation. ATG16L1 p...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:EMBO Rep
Main Authors: Alsaadi, Reham M, Losier, Truc T, Tian, Wensheng, Jackson, Anne, Guo, Zhihao, Rubinsztein, David C, Russell, Ryan C
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6607016/
https://ncbi.nlm.nih.gov/pubmed/31267703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201846885
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