Oral Administration of Caffeine Exacerbates Cisplatin-Induced Hearing Loss

Adenosine A(1) receptors (A(1)AR) are well characterized for their role in cytoprotection. Previous studies have demonstrated the presence of these receptors in the cochlea where their activation were shown to suppress cisplatin-induced inflammatory response and the resulting ototoxicity. Inhibition...

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Udgivet i:Sci Rep
Main Authors: Sheth, Sandeep, Sheehan, Kelly, Dhukhwa, Asmita, Al Aameri, Raheem F. H., Mamillapalli, Chaitanya, Mukherjea, Debashree, Rybak, Leonard P., Ramkumar, Vickram
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606569/
https://ncbi.nlm.nih.gov/pubmed/31267026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45964-9
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