Functional evaluation of variants of unknown significance in the BRCA2 gene identified in genetic testing

Heterozygous germline BRCA2 mutations predispose to breast, ovarian, pancreatic and other types of cancer. The presence of a pathogenic mutation in patients or their family members warrants close surveillance or prophylactic surgery. Besides clearly pathogenic mutations, variants leading only to a s...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Biol Ther
Egile Nagusiak: Heczkova, Marie, Machackova, Eva, Macinga, Peter, Gallmeier, Eike, Cahova, Monika, Spicak, Julius, Jirsa, Milan, Foretova, Lenka, Hucl, Tomas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2019
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606029/
https://ncbi.nlm.nih.gov/pubmed/30638113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2018.1550566
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