Assessment of Rare BRCA1 and BRCA2 Variants of Unknown Significance Using Hierarchical Modeling

Current evidence suggests that the genetic risk of breast cancer may be caused primarily by rare variants. However, while classification of protein-truncating mutations as deleterious is relatively straightforward, distinguishing as deleterious or neutral the large number of rare missense variants i...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Capanu, Marinela, Concannon, Patrick, Haile, Robert W., Bernstein, Leslie, Malone, Kathleen E., Lynch, Charles F., Liang, Xiaolin, Teraoka, Sharon N., Diep, Anh T., Thomas, Duncan C., Bernstein, Jonine L., Begg, Colin B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111904/
https://ncbi.nlm.nih.gov/pubmed/21520273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.20587
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak