Classification of BRCA1 missense variants of unknown clinical significance

Background: BRCA1 is a tumour suppressor with pleiotropic actions. Germline mutations in BRCA1 are responsible for a large proportion of breast–ovarian cancer families. Several missense variants have been identified throughout the gene but because of lack of information about their impact on the fun...

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Detalhes bibliográficos
Main Authors: Phelan, C, Dapic, V, Tice, B, Favis, R, Kwan, E, Barany, F, Manoukian, S, Radice, P, van der Luijt, R B, van Nesselrooij, B P M, Chenevix-Trench, G, kConFab, Caldes, T, de La Hoya, M, Lindquist, S, Tavtigian, S, Goldgar, D, Borg, A, Narod, S, Monteiro, A
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2005
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1735988/
https://ncbi.nlm.nih.gov/pubmed/15689452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2004.024711
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