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Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?
INTRODUCTION: Many of the DNA sequence variants identified in the breast cancer susceptibility gene BRCA1 remain unclassified in terms of their potential pathogenicity. Both multifactorial likelihood analysis and functional approaches have been proposed as a means to elucidate likely clinical signif...
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| 主要な著者: | , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2007
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| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2246181/ https://ncbi.nlm.nih.gov/pubmed/18036263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr1826 |
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