Evaluation of KRAS, NRAS and BRAF hotspot mutations detection for patients with metastatic colorectal cancer using direct DNA pipetting in a fully-automated platform and Next-Generation Sequencing for laboratory workflow optimisation

BACKGROUND: Assessment of KRAS, NRAS (RAS) and BRAF mutations is a standard in the management of patients with metastatic colorectal cancer (mCRC). Mutations could be assessed using next-generation sequencing (NGS) or real-time PCR-based assays. Times to results are 1 to 2 weeks for NGS and 1 to 3 d...

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Publicado en:PLoS One
Autores principales: Gilson, Pauline, Franczak, Claire, Dubouis, Ludovic, Husson, Marie, Rouyer, Marie, Demange, Jessica, Perceau, Marie, Leroux, Agnès, Merlin, Jean-Louis, Harlé, Alexandre
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2019
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605656/
https://ncbi.nlm.nih.gov/pubmed/31265477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219204
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