Motor Cortex Layer V Pyramidal Neurons Exhibit Dendritic Regression, Spine Loss, and Increased Synaptic Excitation in the Presymptomatic hSOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis

Motor cortex layer V pyramidal neurons (LVPNs) regulate voluntary control of motor output and selectively degenerate (along with lower motor neurons) in amyotrophic lateral sclerosis. Using dye-filling and whole-cell patch clamping in brain slices, together with high-resolution spinning disk confoca...

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Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Fogarty, Matthew J., Noakes, Peter G., Bellingham, Mark C.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2015
Assuntos:
Brief Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605367/
https://ncbi.nlm.nih.gov/pubmed/25589758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3483-14.2015
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