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Motor Cortex Layer V Pyramidal Neurons Exhibit Dendritic Regression, Spine Loss, and Increased Synaptic Excitation in the Presymptomatic hSOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis
Motor cortex layer V pyramidal neurons (LVPNs) regulate voluntary control of motor output and selectively degenerate (along with lower motor neurons) in amyotrophic lateral sclerosis. Using dye-filling and whole-cell patch clamping in brain slices, together with high-resolution spinning disk confoca...
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| Udgivet i: | J Neurosci |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Society for Neuroscience
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6605367/ https://ncbi.nlm.nih.gov/pubmed/25589758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3483-14.2015 |
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