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Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is characterised by the death of upper (corticospinal) and lower motor neurons (MNs) with progressive muscle weakness. This incurable disease is clinically heterogeneous and its aetiology remains unknown. Increased excitability of corticospinal MNs has been observ...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Fogarty, Matthew J., Mu, Erica W. H., Noakes, Peter G., Lavidis, Nickolas A., Bellingham, Mark C.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973034/
https://ncbi.nlm.nih.gov/pubmed/27488828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0347-y
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