Neuromodulatory Effect of Gα(s)- or Gα(q)-Coupled G-Protein-Coupled Receptor on NMDA Receptor Selectively Activates the NMDA Receptor/Ca(2+)/Calcineurin/cAMP Response Element-Binding Protein-Regulated Transcriptional Coactivator 1 Pathway to Effectively Induce Brain-Derived Neurotrophic Factor Expression in Neurons

Although coordinated molecular signaling through excitatory and modulatory neurotransmissions is critical for the induction of immediate early genes (IEGs), which lead to effective changes in synaptic plasticity, the intracellular mechanisms responsible remain obscure. Here we measured the expressio...

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Publicat a:J Neurosci
Autors principals: Fukuchi, Mamoru, Tabuchi, Akiko, Kuwana, Yuki, Watanabe, Shinjiro, Inoue, Minami, Takasaki, Ichiro, Izumi, Hironori, Tanaka, Ayumi, Inoue, Ran, Mori, Hisashi, Komatsu, Hidetoshi, Takemori, Hiroshi, Okuno, Hiroyuki, Bito, Haruhiko, Tsuda, Masaaki
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605314/
https://ncbi.nlm.nih.gov/pubmed/25855176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3650-14.2015
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