Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization

Chorea-acanthocytosis (ChAc) is a fatal neurological disorder characterized by red blood cell acanthocytes and striatal neurodegeneration. Recently, severe cell membrane disturbances based on depolymerized cortical actin and an elevated Lyn kinase activity in erythrocytes from ChAc patients were ide...

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Detaylı Bibliyografya
Yayımlandı:J Neurosci
Asıl Yazarlar: Stanslowsky, Nancy, Reinhardt, Peter, Glass, Hannes, Kalmbach, Norman, Naujock, Maximilian, Hensel, Niko, Lübben, Verena, Pal, Arun, Venneri, Anna, Lupo, Francesca, De Franceschi, Lucia, Claus, Peter, Sterneckert, Jared, Storch, Alexander, Hermann, Andreas, Wegner, Florian
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Society for Neuroscience 2016
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604921/
https://ncbi.nlm.nih.gov/pubmed/27881786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0456-16.2016
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