Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization

Chorea-acanthocytosis (ChAc) is a fatal neurological disorder characterized by red blood cell acanthocytes and striatal neurodegeneration. Recently, severe cell membrane disturbances based on depolymerized cortical actin and an elevated Lyn kinase activity in erythrocytes from ChAc patients were ide...

詳細記述

保存先:
書誌詳細
出版年:J Neurosci
主要な著者: Stanslowsky, Nancy, Reinhardt, Peter, Glass, Hannes, Kalmbach, Norman, Naujock, Maximilian, Hensel, Niko, Lübben, Verena, Pal, Arun, Venneri, Anna, Lupo, Francesca, De Franceschi, Lucia, Claus, Peter, Sterneckert, Jared, Storch, Alexander, Hermann, Andreas, Wegner, Florian
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2016
主題:
Research Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604921/
https://ncbi.nlm.nih.gov/pubmed/27881786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0456-16.2016
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