Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization

Chorea-acanthocytosis (ChAc) is a fatal neurological disorder characterized by red blood cell acanthocytes and striatal neurodegeneration. Recently, severe cell membrane disturbances based on depolymerized cortical actin and an elevated Lyn kinase activity in erythrocytes from ChAc patients were ide...

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Pubblicato in:J Neurosci
Autori principali: Stanslowsky, Nancy, Reinhardt, Peter, Glass, Hannes, Kalmbach, Norman, Naujock, Maximilian, Hensel, Niko, Lübben, Verena, Pal, Arun, Venneri, Anna, Lupo, Francesca, De Franceschi, Lucia, Claus, Peter, Sterneckert, Jared, Storch, Alexander, Hermann, Andreas, Wegner, Florian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2016
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604921/
https://ncbi.nlm.nih.gov/pubmed/27881786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0456-16.2016
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