Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization

Chorea-acanthocytosis (ChAc) is a fatal neurological disorder characterized by red blood cell acanthocytes and striatal neurodegeneration. Recently, severe cell membrane disturbances based on depolymerized cortical actin and an elevated Lyn kinase activity in erythrocytes from ChAc patients were ide...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Stanslowsky, Nancy, Reinhardt, Peter, Glass, Hannes, Kalmbach, Norman, Naujock, Maximilian, Hensel, Niko, Lübben, Verena, Pal, Arun, Venneri, Anna, Lupo, Francesca, De Franceschi, Lucia, Claus, Peter, Sterneckert, Jared, Storch, Alexander, Hermann, Andreas, Wegner, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604921/
https://ncbi.nlm.nih.gov/pubmed/27881786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0456-16.2016
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