Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate (11)C-Metoclopramide Assessed with PET Imaging in Humans

PET with avid substrates of P-glycoprotein (ABCB1) provided evidence of the role of this efflux transporter in effectively restricting the brain penetration of its substrates across the human blood–brain barrier (BBB). This may not reflect the situation for weak ABCB1 substrates including several an...

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Bibliografiska uppgifter
I publikationen:J Nucl Med
Huvudupphovsmän: Tournier, Nicolas, Bauer, Martin, Pichler, Verena, Nics, Lukas, Klebermass, Eva-Maria, Bamminger, Karsten, Matzneller, Peter, Weber, Maria, Karch, Rudolf, Caillé, Fabien, Auvity, Sylvain, Marie, Solène, Jäger, Walter, Wadsak, Wolfgang, Hacker, Marcus, Zeitlinger, Markus, Langer, Oliver
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society of Nuclear Medicine 2019
Ämnen:
Neurology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604692/
https://ncbi.nlm.nih.gov/pubmed/30630940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.118.219972
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