Impaired Clearance From the Brain Increases the Brain Exposure to Metoclopramide in Elderly Subjects

The antiemetic and gastroprokinetic drug metoclopramide is a weak substrate of the blood‐brain barrier (BBB) efflux transporter P‐gp and displays central nervous system (CNS) side effects (i.e., extrapyramidal symptoms and tardive dyskinesia) caused by dopamine D(2) receptor blockade in the basal ga...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Bauer, Martin, Bamminger, Karsten, Pichler, Verena, Weber, Maria, Binder, Simon, Maier‐Salamon, Alexandra, Tahir, Ammar, Jäger, Walter, Haslacher, Helmuth, Tournier, Nicolas, Hacker, Marcus, Zeitlinger, Markus, Langer, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7983943/
https://ncbi.nlm.nih.gov/pubmed/32966590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2052
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