Impaired Clearance From the Brain Increases the Brain Exposure to Metoclopramide in Elderly Subjects

The antiemetic and gastroprokinetic drug metoclopramide is a weak substrate of the blood‐brain barrier (BBB) efflux transporter P‐gp and displays central nervous system (CNS) side effects (i.e., extrapyramidal symptoms and tardive dyskinesia) caused by dopamine D(2) receptor blockade in the basal ga...

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Detalles Bibliográficos
Publicado en:Clin Pharmacol Ther
Main Authors: Bauer, Martin, Bamminger, Karsten, Pichler, Verena, Weber, Maria, Binder, Simon, Maier‐Salamon, Alexandra, Tahir, Ammar, Jäger, Walter, Haslacher, Helmuth, Tournier, Nicolas, Hacker, Marcus, Zeitlinger, Markus, Langer, Oliver
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7983943/
https://ncbi.nlm.nih.gov/pubmed/32966590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2052
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