Impaired Clearance From the Brain Increases the Brain Exposure to Metoclopramide in Elderly Subjects

The antiemetic and gastroprokinetic drug metoclopramide is a weak substrate of the blood‐brain barrier (BBB) efflux transporter P‐gp and displays central nervous system (CNS) side effects (i.e., extrapyramidal symptoms and tardive dyskinesia) caused by dopamine D(2) receptor blockade in the basal ga...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Clin Pharmacol Ther
Autori principali: Bauer, Martin, Bamminger, Karsten, Pichler, Verena, Weber, Maria, Binder, Simon, Maier‐Salamon, Alexandra, Tahir, Ammar, Jäger, Walter, Haslacher, Helmuth, Tournier, Nicolas, Hacker, Marcus, Zeitlinger, Markus, Langer, Oliver
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7983943/
https://ncbi.nlm.nih.gov/pubmed/32966590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2052
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