Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate (11)C-Metoclopramide Assessed with PET Imaging in Humans

PET with avid substrates of P-glycoprotein (ABCB1) provided evidence of the role of this efflux transporter in effectively restricting the brain penetration of its substrates across the human blood–brain barrier (BBB). This may not reflect the situation for weak ABCB1 substrates including several an...

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Detalhes bibliográficos
Publicado no:J Nucl Med
Main Authors: Tournier, Nicolas, Bauer, Martin, Pichler, Verena, Nics, Lukas, Klebermass, Eva-Maria, Bamminger, Karsten, Matzneller, Peter, Weber, Maria, Karch, Rudolf, Caillé, Fabien, Auvity, Sylvain, Marie, Solène, Jäger, Walter, Wadsak, Wolfgang, Hacker, Marcus, Zeitlinger, Markus, Langer, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: Society of Nuclear Medicine 2019
Assuntos:
Neurology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604692/
https://ncbi.nlm.nih.gov/pubmed/30630940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.118.219972
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