Comparison of CDH1 Penetrance Estimates in Clinically Ascertained Families vs Families Ascertained for Multiple Gastric Cancers

IMPORTANCE: CDH1 pathogenic variants have been estimated to confer a 40% to 70% and 56% to 83% lifetime risk for gastric cancer in men and women, respectively. These are likely to be overestimates owing to ascertainment of families with multiple cases of gastric cancer. To our knowledge, there are n...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JAMA Oncol
Prif Awduron: Roberts, Maegan E., Ranola, John Michael O., Marshall, Megan L., Susswein, Lisa R., Graceffo, Sara, Bohnert, Kelsey, Tsai, Ginger, Klein, Rachel T., Hruska, Kathleen S., Shirts, Brian H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Medical Association 2019
Pynciau:
Original Investigation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604087/
https://ncbi.nlm.nih.gov/pubmed/31246251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2019.1208
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