Comparison of CDH1 Penetrance Estimates in Clinically Ascertained Families vs Families Ascertained for Multiple Gastric Cancers

IMPORTANCE: CDH1 pathogenic variants have been estimated to confer a 40% to 70% and 56% to 83% lifetime risk for gastric cancer in men and women, respectively. These are likely to be overestimates owing to ascertainment of families with multiple cases of gastric cancer. To our knowledge, there are n...

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Detalles Bibliográficos
Publicado en:JAMA Oncol
Main Authors: Roberts, Maegan E., Ranola, John Michael O., Marshall, Megan L., Susswein, Lisa R., Graceffo, Sara, Bohnert, Kelsey, Tsai, Ginger, Klein, Rachel T., Hruska, Kathleen S., Shirts, Brian H.
Formato: Artigo
Idioma:Inglês
Publicado: American Medical Association 2019
Assuntos:
Original Investigation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604087/
https://ncbi.nlm.nih.gov/pubmed/31246251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2019.1208
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