Comparison of CDH1 Penetrance Estimates in Clinically Ascertained Families vs Families Ascertained for Multiple Gastric Cancers

IMPORTANCE: CDH1 pathogenic variants have been estimated to confer a 40% to 70% and 56% to 83% lifetime risk for gastric cancer in men and women, respectively. These are likely to be overestimates owing to ascertainment of families with multiple cases of gastric cancer. To our knowledge, there are n...

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Bibliographische Detailangaben
Veröffentlicht in:JAMA Oncol
Hauptverfasser: Roberts, Maegan E., Ranola, John Michael O., Marshall, Megan L., Susswein, Lisa R., Graceffo, Sara, Bohnert, Kelsey, Tsai, Ginger, Klein, Rachel T., Hruska, Kathleen S., Shirts, Brian H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Medical Association 2019
Schlagworte:
Original Investigation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604087/
https://ncbi.nlm.nih.gov/pubmed/31246251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2019.1208
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