Penetrance and Expressivity of MSH6 Germline Mutations in Seven Kindreds Not Ascertained by Family History

Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by inherited mutations in DNA mismatch-repair genes, most commonly MLH1 or MSH2. The role MSH6 plays in inherited cancer susceptibility is less well defined. The aim of this study was to investigate the penetrance and expressivity of MSH6 m...

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Main Authors: Buttin, Barbara M., Powell, Matthew A., Mutch, David G., Babb, Sheri A., Huettner, Phyllis C., Edmonston, Tina Bocker, Herzog, Thomas J., Rader, Janet S., Gibb, Randall K., Whelan, Alison J., Goodfellow, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Human Genetics 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182090/
https://ncbi.nlm.nih.gov/pubmed/15098177
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