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Structural insights into the ability of nucleoplasmin to assemble and chaperone histone octamers for DNA deposition

Nucleoplasmin (NP) is a pentameric histone chaperone that regulates the condensation state of chromatin in different cellular processes. We focus here on the interaction of NP with the histone octamer, showing that NP could bind sequentially the histone components to assemble an octamer-like particl...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Franco, Aitor, Arranz, Rocío, Fernández-Rivero, Noelia, Velázquez-Campoy, Adrián, Martín-Benito, Jaime, Segura, Joan, Prado, Adelina, Valpuesta, José M., Muga, Arturo
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602930/
https://ncbi.nlm.nih.gov/pubmed/31263230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45726-7
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