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Alcohol-induced interleukin-17 expression causes murine lung fibroblast-to-myofibroblast transdifferentiation via Thy-1 downregulation

BACKGROUND: Alcohol exposure induces TGFβ1 and renders the lung susceptible to injury and disrepair. We determined that TGFβ1 regulates myofibroblast differentiation through the loss of Thy-1 expression and consequent induction of α-SMA. TGFβ1 is important for T helper 17 (Th17) differentiation and...

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Publicat a:Alcohol Clin Exp Res
Autors principals: Neveu, Wendy A., Staitieh, Bashar S., Mills, Stephen T., Guidot, David M., Sueblinvong, Viranuj
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602829/
https://ncbi.nlm.nih.gov/pubmed/31081931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.14110
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