Cell-Based Screen Using Amyloid Mimic β23 Expression Identifies Peucedanocoumarin III as a Novel Inhibitor of α-Synuclein and Huntingtin Aggregates

Aggregates of disease-causing proteins dysregulate cellular functions, thereby causing neuronal cell loss in diverse neurodegenerative diseases. Although many in vitro or in vivo studies of protein aggregate inhibitors have been performed, a therapeutic strategy to control aggregate toxicity has not...

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Publicado no:Mol Cells
Main Authors: Ham, Sangwoo, Kim, Hyojung, Hwang, Seojin, Kang, Hyunook, Yun, Seung Pil, Kim, Sangjune, Kim, Donghoon, Kwon, Hyun Sook, Lee, Yun-Song, Cho, MyoungLae, Shin, Heung-Mook, Choi, Heejung, Chung, Ka Young, Ko, Han Seok, Lee, Gum Hwa, Lee, Yunjong
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Molecular and Cellular Biology 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602149/
https://ncbi.nlm.nih.gov/pubmed/31250621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2019.0091
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