VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2

Vacuolar protein sorting-associated protein 35 (VPS35) is involved in retrograde transport of proteins from endosomes to trans-Golgi network. Gene mutations in VPS35 are linked to autosomal dominant late-onset Parkinson's disease (PD). Although the identification of VPS35 mutations has provided...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Yun, Seung Pil, Kim, Hyojung, Ham, Sangwoo, Kwon, Seung-Hwan, Lee, Gum Hwa, Shin, Joo-Ho, Lee, Sang Hun, Ko, Han Seok, Lee, Yunjong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477581/
https://ncbi.nlm.nih.gov/pubmed/28383562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.157
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