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Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting
Mutations in a number of genes cause familial forms of Parkinson’s disease (PD), including mutations in the vacuolar protein sorting 35 ortholog (VPS35) and parkin genes. In this study, we identify a novel functional interaction between parkin and VPS35. We demonstrate that parkin interacts with and...
Tallennettuna:
| Julkaisussa: | Hum Mol Genet |
|---|---|
| Päätekijät: | , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6121197/ https://ncbi.nlm.nih.gov/pubmed/29893854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy224 |
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