Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting

Mutations in a number of genes cause familial forms of Parkinson’s disease (PD), including mutations in the vacuolar protein sorting 35 ortholog (VPS35) and parkin genes. In this study, we identify a novel functional interaction between parkin and VPS35. We demonstrate that parkin interacts with and...

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Bibliografiske detaljer
Udgivet i:Hum Mol Genet
Main Authors: Williams, Erin T, Glauser, Liliane, Tsika, Elpida, Jiang, Haisong, Islam, Shariful, Moore, Darren J
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6121197/
https://ncbi.nlm.nih.gov/pubmed/29893854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy224
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