Conversion of Synthetic Aβ to In Vivo Active Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model

The aggregation of amyloid-β peptide (Aβ) in brain is an early event and hallmark of Alzheimer's disease (AD). We combined the advantages of in vitro and in vivo approaches to study cerebral β-amyloidosis by establishing a long-term hippocampal slice culture (HSC) model. While no Aβ deposition...

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Publicat a:J Neurosci
Autors principals: Novotny, Renata, Langer, Franziska, Mahler, Jasmin, Skodras, Angelos, Vlachos, Andreas, Wegenast-Braun, Bettina M., Kaeser, Stephan A., Neher, Jonas J., Eisele, Yvonne S., Pietrowski, Marie J., Nilsson, K. Peter R., Deller, Thomas, Staufenbiel, Matthias, Heimrich, Bernd, Jucker, Mathias
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2016
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601857/
https://ncbi.nlm.nih.gov/pubmed/27147660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0258-16.2016
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