Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies

Typical crystallizable fragment (Fc) glycans attached to the CH2 domain in therapeutic monoclonal antibodies (mAbs) are core-fucosylated and asialo-biantennary complex-type glycans, e.g., G2F (full galactosylation), G1aF (terminal galactosylation on the Man α1-6 arm), G1bF (terminal galactosylation...

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Publicado no:MAbs
Main Authors: Aoyama, Michihiko, Hashii, Noritaka, Tsukimura, Wataru, Osumi, Kenji, Harazono, Akira, Tada, Minoru, Kiyoshi, Masato, Matsuda, Akio, Ishii-Watabe, Akiko
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601563/
https://ncbi.nlm.nih.gov/pubmed/30990348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1608143
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