The influence of antibody engineering on Fc conformation and Fc receptor binding properties: Analysis of FcRn-binding engineered antibodies and an Fc fusion protein

Therapeutic immunoglobulin G (IgG) antibodies have comparatively long half-lives because the neonatal Fc receptor (FcRn) binds to the IgG Fc at acidic pH in the endosome and protects IgG from degradation. To further prolong the half-lives, amino acid-substituted antibodies having high affinity to Fc...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Suzuki, Takuo, Hashii, Noritaka, Tada, Minoru, Ishii-Watabe, Akiko
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2021
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Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8158039/
https://ncbi.nlm.nih.gov/pubmed/34030575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2021.1923366
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